科学研究

陈政

 

:0451-86402029

Email:chenzheng@hit.edu.cn
研究领域:炎症与代谢类疾病分子机制研究

陈政博士2009年毕业于中国科学院生物物理研究所获得博士学位,2009-2015年在美国密歇根大学分子整合生理系从事研究工作,2015-2018年受聘东北师范大学生命科学学院教授。陈博士于2018年加入哈尔滨工业大学生命科学中心/生命科学技术学院。

 

研究兴趣

陈博士实验室长期从事炎症与代谢类疾病分子机制研究,实验室有三个研究方向:

1)研究NF-kB2信号通路在炎症和代谢类疾病中的作用机制,研究NF-kB2信号通路成为药物靶点的可能性;

2)研究RNA表观遗传(lncRNARNA修饰)在NF-kB2信号调控中的作用机制;

3)研究RNA表观遗传(lncRNARNA修饰)在肥胖和糖尿病中的作用和调控机制。

 

实验室的技术与工具

基因敲除小鼠/肥胖糖尿病小鼠

原代细胞分离和培养

腺病毒过表达/敲低

葡萄糖代谢检测与分析

脂质代谢检测与分析

RNA修饰检测与分析

RNA pull down/RIP

分子和细胞生物学技术

 

代表性著作

  1. Ren  X, Li X, Jia L, Chen D, Hou H, Rui L, Zhao Y,Chen  Z*.A  small-molecular inhibitor of NFkB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress,and  injury.FASEB Journal.2017  31(2):711-718

  2. Tao  L, Jia L, Li Y, Song C,Chen  Z*.Recent  advances of adapter proteins in the regulation of heart diseases.Heart Fail Rev.2017  22(1):99-107

  3. Chen Z*.Adapter proteins regulate insulin resistance and lipid metabolism in obesity.Science  Bulletin. 2016

    61:1489-1497

  4. Qin  W, Li X, Xie L, Li S, Liu J, Jia L, Dong X, Ren X, Xiao J, Yang C, Zhou Y, and  Chen

    Z*.A  long  non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR  in

    mice.Nucleic  Acids  Research.2016  44(13):6423-33.

  5. Chen Z*.Progress  and prospects of long noncoding RNAs in lipid homeostasis.Molecular

    Metabolism.20165(3),  164-170.

  6. Ramakrishnan  SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K,Chen  Z,Uhler  MD, Rui L,

    Gonzalez FJ, Shah YM.HIF2α  Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response

     Independent of Insulin Signaling.Cell  Metab.2016  Mar 8;23(3):505-16.

  7. Chen Z.,  Canet, M. J., Sheng, L., Jiang, L., Xiong, Y., Yin, L., and Rui, L. Hepatocyte  TRAF3 promotes insulin resistance and type 2 diabetes in mice with  obesity.Molecular  Metabolism.2015  4, 951-960

  8. Jiang  B, Shen H,Chen  Z,  Yin L, Zan L, Rui L.Carboxyl  terminus of HSC70-interacting protein (CHIP) downregulates NF-κB-inducing kinase  (NIK) and suppresses NIK-induced liver injury.J  Biol Chem.2015  May 1;290(18):11704-14.

  9. Chen  Z, Shen H, Sun C, Yin L, Tang F, Zheng P, Liu Y, Brink R, Rui  L.Myeloid Cell TRAF3 Promotes Metabolic Inflammation, Insulin  Resistance, and Hepatic Steatosis in Obesity.Am  J Physiol Endocrinol Metab.2015 Mar 15;308(6):E460-9.

  10. Sun  J, Cui J, He Q,Chen  Z,  Arvan P, Liu M.Proinsulin  misfolding and endoplasmic reticulum stress during the development and  progression of diabetes.Mol  Aspects Med. 2015  Jan 8. pii: S0098-2997(15)00002-3.

  11. Shen  H, Sheng L,Chen  Z, Jiang  L, Su H, Yin L, Omary MB, Rui L.Mouse  hepatocyte overexpression of NF-κB-inducing kinase (NIK) triggers fatal  macrophage-dependent liver injury and fibrosis.Hepatology.2014  Dec;60 (6):2065-76.

  12. Yuan  Q*,Chen  Z* (co-first  author), Santulli  G, Gu L, Yang ZG, Yuan ZQ, Zhao YT, Xin HB, Deng KY, Wang SQ, Ji G. Functional  role of calstabin 2 in age-related cardiac alterations.Sci  Rep.2014  Dec 11;4:7425.

  13. Chen Z, Morris DL, Lin J, Liu Y, Rui L.SH2B1  in β cells regulates glucosemetabolism  by promoting β cell survival and islet expansion.Diabetes.2014, 63 (2), 585-595

  14. Chen Z, Morris  DL, Lin J, Liu Y, Rui L. SH2B1 in β cells promotes insulin expression and  glucose metabolism in mice.Molecular  Endocrinology.2014,  28 (5), 696-705

  15. Sheng  L, Liu Y, Jiang L,Chen  Z,  Zhou Y, Cho KW, Rui L. Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism  and VLDL secretion in mice.PloS  One. 2013,  8(12):e83269.

  16. Chen Zheng.Nuclear Medicine Contributes to the Identification of Brown Adipose  Tissue in Adult Human.J  Nucl Med Radiat Ther.2012,  3:5 (Editorial Article)

  17. Sheng  L, Zhou Y,Chen  Z,  Ren D, Cho KW, Jiang L, Shen H, Sasaki Y, Rui L.,NF-kB-inducing  Kinase (NIK) Promotes Hyperglycemia and Glucose Intolerance in Obesity by  Augmenting Glucagon Action.Nature  medicine.2012,  18: 943-949

  18. Shen  H, Shao M, Cho KW, Wang S,Chen  Z, Sheng  L, Wang T, Liu Y, Rui L. Herbal Constituent Sequoyitol Improves Hyperglycemia  and Glucose Intolerance by Targeting Hepatocytes, Adipocytes,  andβcells.Am J Physiol Endocrinol Metab.2012, 302 (8): E932-40.

  19. Chen  Z, Sheng  L, Shen H, Zhao Y, Wang S, Brink R, Rui L. Hepatic TRAF2 regulates glucose  metabolism through enhancing glucagon responses.Diabetes.2012,  61:566-573.

  20. Pan  C, Zhou R,Chen  Z,  Chen Y, Wu Y, Miao L, Yin W, Ji G.ERp44  Mediates Gene Transcription via Inositol 1, 4, 5-trisphosphate Receptors in Hela  Cells.Progress  in Biochemistry and Biophysics.2011,  38(8): 706~712.

  21. Tong  X,Muchnik  M,Chen  Z,Patel  M,Wu  N,Joshi  S,Rui  L,Lazar  MA,Yin  L. Transcriptional Repressor E4 Binding Protein 4 (E4BP4) Regulates  Metabolic Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles  and Feeding.J Biol Chem.2010285(47):36401-9

  22. Wang  X,Xie  W,Zhang  Y,Lin  P,Han  L,Han  P,Wang  Y,Chen  Z,Ji  G,Zheng  M,Weisleder  N,Xiao  RP,Takeshima  H,Ma  J,Cheng  H.Cardioprotection of Ischemia/Reperfusion Injury by  Cholesterol-Dependent MG53-Mediated Membrane Repair.Circ  Res.2010 107(1):76-83.

  23. Chen Z, Li Z, Wei B, Yin W, Xu T, Kotlikoff MI, Ji G.FKBP12.6-knockout  mice display hyperinsulinemia and resistance to high-fat diet-induced  hyperglycemia.FASEB  J.2010  24: 357-363.

  24. Zhang  X*, Tallini YN*,Chen  Z*(co-first  author),  Gan L, Wei B, Doran R, Miao L, Xin HB, Kotlikoff MI, Ji G.Dissociation  of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but  not beta-adrenergic stimulation in mouse  cardiomyocytes.Cardiovasc  Res. 2009 Nov 1;84(2):253-62.

  25. Chen Z, Li Z, Peng G, Chen X, Yin W, Kotlikoff MI, Yuan ZQ, Ji  G.Extracellular  ATP-induced nuclear Ca2+ transient is mediated by inositol 1,4,5-trisphosphate  receptors in mouse pancreatic beta-cells.Biochem  Biophys Res Commun. 2009 May 1;382(2):381-4.

  26. Wei  B*,Chen  Z*(co-first  author), Zhang  X, Feldman M, Dong XZ, Doran R, Zhao BL, Yin WX, Kotlikoff MI, Ji  G.Nitric  oxide mediates stretch-induced Ca2+ release via activation of  phosphatidylinositol 3-kinase-Akt pathway in smooth  muscle.PLoS  One. 2008 Jun 25;3(6):e2526.

  27. Zhang  LQ*, Zhang HJ*, Guo P, Xue P, Xie ZS,Chen  Z,  Jing GZ.C-terminal  effect of Thermoanaerobacter tengcongensis ribosome recycling factor on its  activity and conformation changes.Arch  Biochem Biophys. 2007  Oct 15;466(2):211-20.

  28. Wang  M,Chen  Z,  Xing Y, Zhang X, Dong XZ, Ji GJ.Localized  Ca2+ uncaging induces Ca2+ release through IP3R in smooth  muscle.Acta  Pharmacol Sin. 2006  Jul;27(7):939-44.