科学研究
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1. Liyong Dong, Xiaoyu Guan, Ningning Li, Fan Zhang, Yuwei Zhu, Kuan Ren, Ling Yu, Fengxia Zhou, Zhifu Han, Ning Gao# & Zhiwei Huang#.

 An anti-CRISPR protein disables type V Cas12a by acetylation. 

Nature Structural & Molecular Biology. 2019 26: 308–314.


2. Yuanzheng He*#, Jingjing Shi*, Quang Tam Nguyen*, Erli You, Hongbo Liu, Xin Ren, Zhongshan Wu, Jianshuang Li, Wenli Qiu, Sok Kean Khoo, Tao Yang, Wei Yi, Feng Sun, Zhijian Xi, Xiaozhu Huang, Karsten Melcher, Booki Min#, and H. Eric Xu#. 

Development of highly potent glucocorticoids for steroid-resistant severe asthma.

 PNAS. 2019 116 (14): 6932-6937.


3. Minghui Guo, Kaiming Zhang, Yuwei Zhu, Grigore D. Pintilie, Xiaoyu Guan, Shanshan Li, Michael F. Schmid, Zhuo Ma, Wah Chiu#& Zhiwei Huang#. 

Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry. 

Cell Research. 2019 29:305-312.


4. Minghui Guo, Kuan Ren, Yuwei Zhu, Ziyun Tang, Yuhang Wang, Bailing Zhang#& Zhiwei Huang#

Structural insights into a high fidelity variant of SpCas9. 

Cell Research. 2019 29:183–192.


5. Gao M*#, Yi J* Zhu J, Minikes A, Monian P, Thompson C, and Jiang X#. 

Role of Mitochondria in Ferroptosis. 

Molecular Cell. 2018 73: 1–10.


6. Li X, Jia L, Chen X, Dong Y, Ren X, Dong Y, Chen Y, Xie L, Liu M, Shiota C, Gittes GK, Rui L, Chen Z*.

Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice.

Theranostics. 2018 8(21):5960-5971.


7. Shifan Yang, Yiran Wu, Ting-Hai Xu, Parker W. de Waal, Yuanzheng He, Mengchen Pu, Yuxiang Chen, Zachary J. DeBruine, Bingjie Zhang, Saheem A. Zaidi, Petr Popov, Yu Guo, Gye Won Han, Yang Lu, Kelly Suino-Powell, Shaowei Dong, Kaleeckal G. Harikumar, Laurence J. Miller, Vsevolod Katritch, H. Eric Xu, Wenqing Shui, Raymond C. Stevens,Karsten Melcher, Suwen Zhao & Fei Xu.  

Crystal structure of the Frizzled 4 receptor in a ligand-free state.

 Nature. 2018 560: 666–670.


8. Jing M, Zhang P, Wang G, Feng J, Mesik L, Zeng J, Jiang H, Wang S, Looby JC, Guagliardo NA, Langma LW, Lu J, Zuo Y, Talmage DA, Role LW, Barrett PQ, Zhang LL, Luo M, Song Y, Zhu JJ and Li Y. 

A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. 

Nature Biotechnology. 2018 36: 726-737.


9. Zhang L*, Zhang P*, Wang G*, Zhang H*, Zhang Y, Yu Y, Zhang M, Xiao J, Crespo P, Hell JW, Lin L, Huganir RL, Zhu JJ. 

Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains. 

Neuron2018 98: 783-800.


10. Gao M#, Jiang X#. 

To Eat or Not to Eat – The Metabolic Flavor of Ferroptosis. 

Current Opinion in Cell Biology. 2018 51:58-64. (#Co-corresponding authors)


11. De Dong*, Minghui Guo*, Sihan Wang*, Yuwei Zhu, Shuo Wang, Zhi Xiong, Jianzheng Yang, Zengliang Xu and Zhiwei Huang#

Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein. 

Nature. 2017 546:436-439. doi: 10.1038/nature22377.


12. Dan Wu*, Xiaoyu Guan *, Yuwei Zhu*, Kuan Ren, Zhiwei Huang#

Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA. 

Cell Research. 2017 27: 705-708. doi: 10.1038/cr.2017.46.