Work Experience

2015 – present     Professor. Northeast Normal University, Changchun

2009 – 2015        Postdoctoral training. Medical School University of Michigan.

Education

2004 – 2009 Ph.D. in Cell biology

Institute of Biophysics, Chinese Academy of Sciences,  Beijing.

2000 – 2004 B.S. in Biotechnology

Shandong Normal University, Jinan.

Honors and Awards

Shandong Normal University scholarship, 2001-2004

Chinese Academy of Sciences scholarship, 2006-2009

Best poster, 3rd University of Michigan-Wayne State University Symposium  2012

Travel Award, Endocrine Society 2014

Selected Publications

1.  Li  X, Jia L, Chen X, Dong Y, Ren X, Dong Y, Chen Y, Xie L, Liu M, Shiota C, Gittes  GK, Rui L, Chen   Z*. Islet  α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to  Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice.  Theranostics 2018 8(21): 5960-5971.
   

2. Ren  X, Li X, Jia L, Chen D, Hou H, Rui L, Zhao Y,Chen  Z*. A  small-molecular inhibitor of NF-kB-inducing kinase (NIK) protects liver from  toxin-induced inflammation, oxidative stress, and  injury.FASEB  Journal.2017  31(2):711-718

3. Tao  L, Jia L, Li Y, Song C,Chen  Z*.Recent  advances of adapter proteins in the regulation of heart  diseases.Heart  Fail Rev.2017  22(1):99-107

4. Chen Z*. Adapter  proteins regulate insulin resistance and lipid metabolism in obesity.Science  Bulletin. 2016  61:1489-1497

5. Qin  W, Li X, Xie L, Li S, Liu J, Jia L, Dong X, Ren X, Xiao J, Yang C, Zhou Y,  andChen  Z*.   A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in  mice.Nucleic  Acids Research.2016  44(13):6423-33.

6. Chen Z*.   Progress and prospects of long noncoding RNAs in lipid  homeostasis.Molecular  Metabolism20165(3),  164-170

7. Ramakrishnan  SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz  K,Chen  Z,  Uhler MD, Rui L, Gonzalez FJ, Shah YM.HIF2α  Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response  Independent of Insulin Signaling.Cell  Metab. 2016  Mar 8;23(3):505-16.

8. Chen  Z.,  Canet, M. J., Sheng, L., Jiang, L., Xiong, Y., Yin, L., and Rui, L. Hepatocyte  TRAF3 promotes insulin resistance and type 2 diabetes in mice with  obesity.Molecular  Metabolism2015  4, 951-960

9. Jiang  B, Shen H,Chen  Z,  Yin L, Zan L, Rui L.Carboxyl  terminus of HSC70-interacting protein (CHIP) downregulates NF-κB-inducing kinase  (NIK) and suppresses NIK-induced liver injury.J Biol  Chem.2015  May 1;290(18):11704-14.

10. Chen  Z, Shen H, Sun C, Yin L, Tang F, Zheng P, Liu Y, Brink R, Rui  L.Myeloid  Cell TRAF3 Promotes Metabolic Inflammation, Insulin Resistance, and Hepatic  Steatosis in Obesity.Am  J Physiol Endocrinol Metab.2015 Mar 15;308(6):E460-9.

11. Sun  J, Cui J, He Q,Chen  Z,  Arvan P, Liu M.Proinsulin  misfolding and endoplasmic reticulum stress during the development and  progression of diabetes.Mol  Aspects Med. 2015  Jan 8. pii: S0098-2997(15)00002-3.

12. Shen  H, Sheng L,Chen  Z, Jiang  L, Su H, Yin L, Omary MB, Rui L.Mouse  hepatocyte overexpression of NF-κB-inducing kinase (NIK) triggers fatal  macrophage-dependent liver injury and fibrosis.Hepatology. 2014  Dec;60 (6):2065-76.

13. Yuan  Q*,Chen  Z* (co-first  author), Santulli  G, Gu L, Yang ZG, Yuan ZQ, Zhao YT, Xin HB, Deng KY, Wang SQ, Ji G. Functional  role of calstabin 2 in age-related cardiac alterations.Sci  Rep.2014  Dec 11;4:7425.

14. Chen Z,  Morris DL, Lin J, Liu Y, Rui L. SH2B1 in β cells regulates glucosemetabolism  by promoting β cell survival and islet expansion.Diabetes.2014,  63 (2), 585-595PMID:  24150605.

15. Chen Z, Morris  DL, Lin J, Liu Y, Rui L. SH2B1 in β cells promotes insulin expression and  glucose metabolism in mice.Molecular  Endocrinology.2014,  28 (5), 696-705 PMID: 24645678.

16. Sheng  L, Liu Y, Jiang L,Chen  Z,  Zhou Y, Cho KW, Rui L. Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism  and VLDL secretion in mice.PloS  One. 2013,  8(12):e83269.

17. Chen Zheng.Nuclear  Medicine Contributes to the Identification of Brown Adipose Tissue in Adult  Human.J  NuclMed  Radiat Ther2012,  3:5 (Editorial Article)

18. Sheng  L, Zhou Y,Chen  Z,  Ren D, Cho KW, Jiang L, Shen H, Sasaki Y, Rui L.,NF-kB-inducing  Kinase (NIK) Promotes Hyperglycemia and Glucose Intolerance in Obesity by  Augmenting Glucagon Action.Nature  medicine.2012,  18: 943-949PMID:  22581287.

19. Shen  H, Shao M, Cho KW, Wang S,Chen  Z, Sheng  L, Wang T, Liu Y, Rui L. Herbal Constituent Sequoyitol Improves Hyperglycemia  and Glucose Intolerance by Targeting Hepatocytes, Adipocytes, and β  cells.Am J Physiol Endocrinol Metab.2012, 302 (8): E932-40. PMCID: PMC3330724.

20. Chen  Z,  Sheng L, Shen H, Zhao Y, Wang S, Brink R, Rui L. Hepatic TRAF2 regulates glucose  metabolism through enhancing glucagon responses.Diabetes2012,  61:566-573. PMCID: PMC3282816.

21. Pan  C, Zhou R,Chen  Z,  Chen Y, Wu Y, Miao L, Yin W, Ji G. ERp44 Mediates Gene Transcription via  Inositol 1, 4, 5-trisphosphate Receptors in Hela Cells.Progress  in Biochemistry and Biophysics2011,  38(8): 706~712.

22. Tong  X,Muchnik  M,Chen  Z,Patel  M,Wu  N,Joshi  S,Rui  L,Lazar  MA,Yin  L.  Transcriptional Repressor E4 Binding Protein 4 (E4BP4) Regulates Metabolic  Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles and  Feeding.J  Biol Chem.2010  285(47):36401-9. PMID:20851878.

23. Wang  X,Xie  W,Zhang  Y,Lin  P,Han  L,Han  P,Wang  Y,Chen  Z,Ji  G,Zheng  M,Weisleder  N,Xiao  RP,Takeshima  H,Ma  J,Cheng  H. Cardioprotection of Ischemia/Reperfusion Injury by  Cholesterol-Dependent MG53-Mediated Membrane Repair.Circ  Res. 2010 107(1):76-83. PMID: 20466981.

24. Chen Z, Li Z, Wei B, Yin W, Xu T, Kotlikoff MI, Ji G.FKBP12.6-knockout  mice display hyperinsulinemia and resistance to high-fat diet-induced  hyperglycemia.FASEB  J.  2010 24: 357-363. PMCID: PMC2812035.

25. Zhang  X*, Tallini YN*,Chen  Z*(co-first author),  Gan L, Wei B, Doran R, Miao L, Xin HB, Kotlikoff MI, Ji G.Dissociation  of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but  not beta-adrenergic stimulation in mouse  cardiomyocytes.Cardiovasc  Res.  2009 Nov 1;84(2):253-62. PMCID: PMC2761199.

26. Chen Z, Li Z, Peng G, Chen X, Yin W, Kotlikoff MI, Yuan ZQ, Ji  G.Extracellular  ATP-induced nuclear Ca2+ transient is mediated by inositol 1,4,5-trisphosphate  receptors in mouse pancreatic beta-cells.BiochemBiophys  Res Commun.  2009 May 1;382(2):381-4. PMID: 19285037.

27. Wei  B*,Chen  Z*(co-first author), Zhang  X, Feldman M, Dong XZ, Doran R, Zhao BL, Yin WX, Kotlikoff MI, Ji  G.Nitric  oxide mediates stretch-induced Ca2+ release via activation of  phosphatidylinositol 3-kinase-Akt pathway in smooth  muscle.PLoS  One.2008  Jun 25;3(6):e2526. PMCID: PMC2424173.

28. Zhang  LQ*, Zhang HJ*, Guo P, Xue P, Xie ZS,Chen  Z,  Jing GZ.C-terminal  effect of Thermoanaerobacter tengcongensis ribosome recycling factor on its  activity and conformation changes.Arch  Biochem Biophys. 2007  Oct 15;466(2):211-20. PMID: 17697668.

29. Wang  M,Chen  Z,  Xing Y, Zhang X, Dong XZ, Ji GJ.Localized  Ca2+ uncaging induces Ca2+ release through IP3R in smooth  muscle.Acta  Pharmacol Sin. 2006  Jul;27(7):939-44. PMID: 16787580.