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2019.06.28 Signaling and metabolic checkpoints in T cells
Publisher:高雪  Time2019-06-26 View:10

Chenqi Xu, Ph.D

Professor,Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Time:14:00pm-16:00pm, 28th June, 2019

Venue:Room 305, Mingde Building

Host:Zhiwei Huang, Professor


Abstract:

T cells are key players in our immune system to fight with cancer cells. However, cancer cells can develop multiple mechanisms to suppress T cell activity to evade immune attack. Signaling suppression and metabolic suppression are the two major parts of immunosuppression, which involves signaling and metabolic checkpoint molecules in T cells. In clinic, blockade antibodies against signaling checkpoints have been successfully applied to treat multiple types of cancer, which highlights the importance of checkpoint biology. In this talk, I will introduce our recent works on the signaling checkpoint PD-1 and the metabolic checkpoint ACAT1. The idea of combination of signaling modulation and metabolic modulation for next-generation cancer immunotherapy will also be discussed.