I. Introduction of the Research Group

Our group focuses on the development of chemical protein labeling (A), chemical genetic and chemo-optogenetic approaches (B) to facilitate the study of frontier biological questions related to cytoskeleton function; (C) we will be particularly interested in understanding the mechanisms underneath metaphase spindle assembly for error-free chromosome segregation during cell division using the cell-free Xenopus laevis frog (i.e. African clawed frog) egg extract system. At the translational research level, (D) we will be interested to rationally design small molecule-protein conjugates as potential therapeutics to treat diseases that are related to genomic instability, including cancer. So far, we have published some of the research results in high profile journals, including Angew. Chem. Int. Ed. (2017, 2018), J. Am. Chem. Soc. (2014), Chem. Commun. (2015), Bioconjugate Chem. (2012) and others. More in-depth research results that deal with the molecular mechanisms will be submitted shortly. Published works have been highlighted as VIP paper, Hot Paper, Cover Story, and have been reported by domestic and overseas scientific media in different languages including Chinese, English, German, Swedish and others. The Principal Investigator also wrote a book chapter (Wiley, 2015), and was awarded a European Invention Patent and PCT patent (2019). More detailed description of the group can be found in the following links:

Webpage (Chinese): http://hcls.hit.edu.cn/2019/1115/c9400a232923/page.htm

Webpage (English): http://hcls.hit.edu.cn/hclsen/2019/1115/c7485a232911/page.htm

II. Description of the Open Positions

Responsibilities of postdoc:

Perform independent research supervised under PI

Qualifications of postdoc candidates:

1. Obtained, or going to obtain a Ph.D. degree in one of the following fields: organic chemistry, chemical biology, protein bioconjugation chemistry, medicinal chemistry, biochemistry, immune cell therapy, mice genetics, gene editing, or molecular biology;

2. Be self-motivated, has good communication skills, and has a high sense of responsibility and team spirit;

3. Shows a deep interest in chemical biology, or life science, and is capable to perform research works independently under the guidance of PI;

4. Self-motivated to learn new knowledges from other disciplines;

Responsibilities of technician:

1. Lab managing, ordering, and other daily stuffs;

2. Perform independent research under the guidance of PI, or work with PI or other members in the group to perform experiments in a collaborative way.

Qualifications of technician candidates:

1. Obtained, or going to obtain a M.Sc. or B.Sc. degree in chemistry, biology, biomedicine, or related fields. Has a research background related to one of the following fields: organic synthesis, chemical biology, protein bioconjugation chemistry, biochemistry, medicinal chemistry, immunology, mice genetics, gene editing, molecular biology, or related fields;

2. Has a deep interest in chemical biology, or life science, and is capable to perform research works under the guidance of PI;

3. Be self-motivated, has good communication skills, and has a high sense of responsibility and team spirit；

4. Self-motivated to learn new knowledges from other disciplines;

5. Opportunity to be converted to Ph.D. candidates is provided.

III. How to Apply

We are seeking for 2 talented postdocs and 2-3 lab technicians. Candidates are expected to have one of the following research background: organic chemistry, protein bioconjugation chemistry, chemical biology, medicinal chemistry, biochemistry, molecular biology, immune cell therapy (e.g. CAR-T), phage display, directed evolution, gene editing, mice genetics, algorithm implementation (e.g. MATLAB, Python, etc.) or related fields, and should have a deep interest in conducting multi-disciplinary research crossing chemistry and life sciences. For application, please send a cover letter and a full CV to PI’s email address: chenxihit@hit.edu.cn. Postdoc candidates who passed the initial interview are expected to provide the contact information of two references and the two reference letters from them. This recruitment will continue until all positions are filled.

Ⅳ.Packages and Benefits

HIT center for life science provides superior scientific research environment and world-class scientific research platform including various cutting-edge instruments. We provide competitive salaries for postdoc and technician positions. Full benefits including insurances and etc. will be offered according to the regulations of HIT.